The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.
Tobey Maguire
Spider-Man / Peter Parker
Kirsten Dunst
Mary Jane Watson
James Franco
New Goblin / Harry Osborn
Thomas Haden Church
Sandman / Flint Marko
Topher Grace
Venom / Eddie Brock
Bryce Dallas Howard
Gwen Stacy
Rosemary Harris
May Parker
J.K. Simmons
J. Jonah Jameson
