Maggie is an alluring free spirit who won't let anyone – or anything – tie her down. But she meets her match in Jamie, whose relentless and nearly infallible charm serves him well with the ladies and the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.
Jake Gyllenhaal
Jamie Randall
Anne Hathaway
Maggie Murdock
Oliver Platt
Bruce Winston
Hank Azaria
Dr. Stan Knight
Josh Gad
Josh Randall
Gabriel Macht
Trey Hannigan
Judy Greer
Cindy
Jill Clayburgh
Nancy Randall
