Set 15 years after "Twentieth Century Boys," Kanna (Airi Taira) reunites with several main characters from the first film in an attempt to stop Friend's increasing influence over the world and continued plans to eliminate humanity, as detailed in the New Book of Prophecy.
Toshiaki Karasawa
Kenji Endo
Etsushi Toyokawa
Otcho
Takako Tokiwa
Yukiji
Airi Taira
Kanna Endo
Nana Katase
Miki Shikishima
Hitomi Kuroki
Kiriko Endo
Eiko Koike
Takasu
Haruka Kinami
Kyoko
